AMAZING HEALTH BENEFITS

Are you searching for a natural and holistic approach to prevent and treat various health concerns? Look no further! Our Pine Needle Tea offers a simple yet powerfully complex solution derived from the leaves (needles) of the Eastern White Pine Tree. For centuries, this medicinal beverage has been revered for its incredible health properties, providing relief and promoting overall well-being.

The key to the exceptional health benefits of Pine Needle Tea lies in its rich composition of over 700 naturally occuring compounds that work together the way nature intended! Let's delve into some of these components and their remarkable effects on our health.

Terpenes, a group of natural phytochemicals abundantly found in pines, form a significant component group of Pine Needle Tea. Extensive research has demonstrated the antiviral, anti-inflammatory, anticancer, and neuroprotective effects of terpenes.

Another crucial component of our Pine Needle Tea is alkaloids, which have demonstrated various therapeutic activities. Studies have shown that alkaloids possess antitumor, anti-hyperglycemic, and antibacterial properties.

Moreover, Pine Needle Tea is packed with a wealth of polyphenols, including flavonoids, lignans, and stilbenes. These natural antioxidants offer an array of health benefits. Flavonoids, the most abundant phenol group in nature and commonly found in pines, exhibit antimicrobial, anticancer, antidiabetic, and anti-inflammatory properties. They can be utilized in the treatment of neurodegenerative diseases, providing a multifaceted approach to health improvement.

One of the most exciting components abundantly present in our Pine Needle Tea is shikimic acid, the precursor for the main ingredient in the popular pharmaceutical antiviral drug Tamiflu™. Shikimic acid also demonstrates potential in combating Staph infections, aiding with the common cold, influenza, and covid as well as preventing and breaking down blood clots within the body.

The benefits of Pine Needle Tea extend far beyond what we can cover here. It would take numerous pages to fully do justice to the extensive medical research conducted on this remarkable beverage. However, we have compiled a brief list of studies, categorized by ailment/disease, to provide you with easy navigation and access to the wealth of information available.

So, why wait? Experience the extraordinary health benefits of Pine Needle Tea today! With its potent blend of natural health producing compounds and centuries of traditional use, this beverage is sure to leave you feeling better, revitalized, and on the path to improved well-being.

Disclaimer: The information provided is not intended to replace professional medical advice, diagnosis, or treatment. Please consult a healthcare professional before incorporating any new product into your wellness routine.



NEURODEGENERATIVE DISORDERS:
(Alzheimer's Disease, Parkinson’s Disease, Dementia, Amnesia, Memory Loss


Chemometric-enhanced metabolic profiling of five Pinus species using HPLC-MS/MS spectrometry: Correlation to in vitro anti-aging, anti-Alzheimer and antidiabetic activities.  Saber FR, Mohsen E, El-Hawary S, Eltanany BM, Elimam H, Sobeh M, Elmotayam AK.  Findings suggested that pine needles are a good source of phenolics and diterpenoids that have possible health promoting activities in management and alleviation of diabetic conditions and Alzheimer disease.

Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a D-galactose-induced mouse model. Wang C, He L, Yan M, Zheng GY, Liu XY.  We have demonstrated that polyprenols may ameliorate memory and cognitive impairment via enhancing oxidative defense and affecting generation and dissimilation of Aβ-related enzymes, suggesting that polyprenols represent a novel drug for treating Alzheimer's disease.

Effect of new polyprenol drug Ropren on anxiety-depressive-like behavior in rats with experimental Alzheimer disease  Fedotova IuO, Sultanov VS, Kuznetsova NN, Roshchin VI, Nikitina TV.  The four-week treatment revealed significant anxiolytic and antidepressant effects of the drug Ropren (made from pine needle extract). Ropren administration improved various behavioral parameters. The obtained results show that ropren ameliorates behavioral deficits in animal model relevant to Alzheimer's disease and indicate that Ropren is potentially active in the management of affective impairments in the experimental model under consideration. It also has a profound beneficial effect on the anxiety and depressive-like behavior in rats with model Alzheimer's type dementia, and thus may prove to be a novel natural treatment. 

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders  Melanie-Jayne R Howes, Nicolette S L Perry, Peter J Houghton  Plants and their constituents with pharmacological activities that may be relevant to the treatment of cognitive disorders, including enhancement of cholinergic function in the central nervous system, anti-cholinesterase (anti-ChE), antiinflammatory, antioxidant and oestrogenic effects, are discussed.

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease  Bushra Shal  Analysis of anti-inflammatory and neuroprotective phytochemicals such as terpenoids, phenolic derivatives, alkaloids, glycosides, and steroidal saponins displays therapeutic potential toward amelioration and prevention of devastating neurodegeneration observed in Alheimer's disease. 

Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens  Vagif Soultanov 
The results indicate that Ropren® (made from pine needles) has a marked antidepressant-like effect in the experimental model of Alzheimer's disease in male rats with altered levels of androgens.

"Pine needle extract prevents hippocampal memory impairment in acute restraint stress mouse model" by Lee et al. - Pine needle extract may prevent stress-induced memory impairment by reducing oxidative stress in the hippocampus, a brain region important for memory and learning.

Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation  Min Ji Go  This study suggests that pine bark extract treatment has an anti-amnestic effect by modulating cholinergic system dysfunction and neuroinflammation in Aβ1-42-induced cognitive impairment in mice.

Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model  Jin-Seok Lee  These findings suggest that Pine Needle Extract could be a potent neuropharmacological drug against amnesia and its possible mechanism might be modulating cholinergic activity via CREB-BDNF pathway.

 

INFLUENZA/FLU:

Inhibitory effects of cedar pine needle extract on H9N2 avian influenza virus in vitro and in vivo  Mingzheng Han - Pine needle extract may inhibit the proliferation of pathogens, regulate the immune response, and reduce host tissue damage and may serve as a potential target for drug development against H9N2 avian influenza virus.



SARS-CoV-2/COVID:


Inhibitory effects of cedar pine needle extract on H9N2 avian influenza virus in vitro and in vivo  Quy Thi Kim Ha - This study demonstrates that P. densiflora can be considered an abundant natural anti-influenza viral source to find new bioactive compounds against influenza virus outbreaks in the future

 

HEART DISEASE:

Bioactivity-Guided Fractionation of Pine Needle Reveals Catechin as an Anti-hypertension Agent via Inhibiting Angiotensin-Converting Enzyme  Jian He  And we found out the compound in pine needle extracts being ACE-inhibitory active is catechin. When ACE activity was assayed in rat tissue membranes, it was observed that catechin demonstrate ACE inhibition in kidney, lung and testes tissue. All these presents catechin in pine needle could be a potential cardiovascular medicine.

Anti-inflammatory properties of fermented pine needle on lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells  Hui-Fang Chiu - The outcome of this study distinctly showed that EAE-FPN displayed potent antioxidant and anti-inflammatory activities by regulating NF-κB signaling pathway. Therefore, pine needle could be developed into functional drink to abolish the progression of inflammatory responses in various disease condition.

 

CANCER:

Study on the antimutagenic effect of pine needle extract  Z. Kong - This suggested that the pine needle extract was an effective antimutagen and it is important to choose the proper doses of pine needle extract for antitumor effect.  

Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway  by Bing Qiu  Based on the data provided in the present study, a conclusion may be drawn that pine needle oil induces G2/M cell cycle arrest by activating the ATM signaling pathways, inhibits proliferation, and balances proliferation and apoptosis in HepG2 cells.

Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer Ren P, Ren X, Cheng L, Xu L. - Frankincense, pine needle and geranium essential oils have been reported to play critical biological activities in cancer.

Pine needle hexane extract promote cell cycle arrest and premature senescence via p27KIP1 upregulation gastric cancer cells  Kim W, Park C, Park J, Cheong H, Kim SJ.  These results showed that Pine Needle Extract inhibited gastric cancer cell proliferation through the induction of G1-cell cycle arrest and premature senescence via induced p27KIP1 expression, as controlled by Skp2 reduction.

Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway Qiu B, Jiang W, Qiu W, Mu W, Qin Y, Zhu Y, Zhang J, Wang Q, Liu D, Qu Z.  The data of the present study indicated that pine needle oil induces G2/M arrest in HepG2 cells by facilitating ATM activation.

Pine needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy  Liao CL, Chen CM, Chang YZ, Liu GY, Hung HC, Hsieh TY, Lin CL.  Results showed that pine needle extract and chrysin may serve as a potential anticancer agent against glioblastoma (cancer).

Pine Needle Extract Applicable to Topical Treatment for the Prevention of Human Papillomavirus Infection  Lee HJ, Park M, Choi H, Nowakowska A, Moon C, Kwak JH, Kim YB.  In conclusion, Pine Needle Extract represents a potential topical virucide for HPV infection.


THROMBOSIS (BLOOD CLOTS):

Antithrombosis activity of protocatechuic and shikimic acids from pine needles  Jaeyoung Park - Pine needle extract (PE) has been reported to show various biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, gastrointestinal motility control, and fibrinolytic effect.  Pine needle extract not only have fibrinolysis activity but also inhibit fibrin formation similar to aspirin.


 

LUNG DISEASE:

Alleviation effects of natural volatile organic compounds from pine needles on systemic and pulmonary inflammation  Changhwan Ahn - Recent studies have demonstrated antioxidant, antiproliferative and anti-inflammatory effects of pine needles.  The results of the present study suggested that volatile organic compounds of pine needles, through their immunosuppressive activities, may have therapeutic potential in the treatment or prevention of inflammation.  

 

INFLAMMATION:

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice  Seul-Yong Jeong - Pine exerts antioxidant and anti-inflammatory effects by inhibiting the production of inflammatory mediators. Identified flavonoids such as taxifolin and quercetin glucoside can be attributed to effect of pine.  


DEPRESSION:


Effects of ethanolic extract of pine needles (Pinus eldarica Medw.) on reserpine-induced depression-like behavior in male Wistar rats  Samira Bolandghamat - These results indicate that ethanolic extract of Pinus eldarica needles possesses an antidepressant activity.  



MIGRAINES:

Clinical research on treatment of migraine with pine needle moxibustion  ZHongguo zhen jiu - The clinical effect of migraine treated with pine needle moxibustion is better than that with the medicated thread moxibustion of Zhuang medicine. And it has obvious regulation effect on the levels of hs-CRP and Mg2+ in the serum of patients.


OBESITY:


Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice  Eun A Kim - This study suggests that Pine Needle Extract has a potent anti-obesity effect, inhibiting lipogenesis in WAT, even though HFD-induced leptin resistance-mediated disruption of POMC neuronal activity. 


Effects of pine needle extract on differentiation of 3T3-L1 preadipocytes and obesity in high-fat diet fed rats  Jeong-Ryae Jeon - In conclusion, PNE treatment suppressed differentiation of 3T-L1 adipocytes, in part by down-regulating expression of PPAPgamma mRNA, and reduced adipose tissue mass, hyperlipidemia, and hepatic steatosis in obese rats fed HFD. Therefore, pine needle water extract may be considered for use in therapy to control obesity.  

 

DIABETES:

Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia  Yong-Mu Kim - Pine extract can be used to suppress postprandial hyperglycemia of diabetic patients. It also can be applied for control of obesity by decreasing the food efficiency ratio, especially carbohydrates.

 

OTHER AILMENTS/DISEASES:

Pine needle extract could promote the expression of PCNA and Ki-67 after partial hepatectomy in rat (liver regeneration)  Gyeong Seok Lee - Pine needle extract stimulates the expression of some mitotic proteins during liver regeneration induced by 70% PH in rats. It suggests that administration of pine needle extract could accelerate the liver regeneration after partial hepatectomy.

Evaluation of In Vitro Antioxidant Activity of the Water Extract Obtained from Dried Pine Needle  Joo-Shin Kim  The PNWE (Pine Needle Water Extract) showed a strong power comparable to those of commercial phenolic compounds in biological systems. These results indicated that the protective activity of PNWE could be due to the presence of naturally-occurring phenolic compounds, which act as potent in vitro antioxidants in both non-cellular and cellular systems.